When Captain Johnathan Archer gets infected with time-space parasites, he loses the ability to form long-term memories from the point of infection. Each day, he wakes up to the surprise that weeks, months, years, and decades have passed. 15-or-so years later, Doctor Phlox announces he may have a cure, but the marauding of the never-defeated Xindi may prevent Archer from undergoing the procedure. Oh, also, T'Pol spent all the years with Archer and formed "feelings" for him. It's as icky as it sounds.
Erik also experiences memory lapses as he and Justin discuss the His Dark Materials novel series. Justin once again praises the charms of star Scott Bakula. But he also notes the lack of fan service otherwise in the episode. Erik points out the way Star Trek: The Next Generation overwhelmed people's perception of Star Trek. Starfleet fashions once again get critiqued, as do the hairstyles in the future. Committing to a bit becomes important. Erik and Justin break down the Enterprise title theme again. The issue of the T'Pol/Archer thing leads Erik to notice an ugly theme in the episode. Dominic Keating gets recast as a villain when Justin and Erik reorder some of the actors, and Doctor What makes a surprise appearance.